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Getsemaní is safe in the main squares like Plaza de la Trinidad, but avoid walking the dark, narrow side streets alone.

May is technically dry season, but the Andes weather is unpredictable, as JakRoberto said. For layers, focus on merino wool base layers (top and bottom) for the evenings and early mornings. You need a good quality, lightweight puffy jacket for camp and a fleece mid-layer for hiking.

Find a group of three or four people and just charter the whole taxi yourself. It's the fastest and most flexible way to make the trip.